Endocrine Abstracts

KML001 is an orally bioavailable and water soluble trivalent arsenic compound having anti-cancer activity via controlling the numerous signaling pathways including phosphoinositide 3-kinase (PI3K)/Akt and extracellular signal-regulated kinase (ERK) signaling pathways. PI3K/Akt and ERK signaling pathways are overactivated in adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma. In this study, we evaluated the effects of KML001 on cell viability, cell cycle, apoptosis,...

Background: The risk of iodine-induced thyrotoxicosis is increased in patients with Graves’ disease and multi nodular goiter with thyroid autonomy. At same time, hypothyroidism can develop after iodine exposure in patients with Hashimoto’s thyroiditis. But, there are no studies about the influence of iodine containing contrast media on thyroid function in iodine excessive area. This study was done to evaluate the changes of thyroid function after coronary angiography...

Objective: The association between albuminuria and peripheral artery disease (PAD) could be confounded by renal function. Albuminuria reflects generalized disruption of endothelial cell function. This study was conducted to examine the association of PAD with low glomerular filtration rate (GFR) and albuminuria in diabetic patients.Methods: A total of 254 diabetic patients were included. We examined the age, sex, duration of diabetes, GFR, urinary albumi...

Obesity is one of the leading causes of elevated cardiovascular disease (CVD) mortality and morbidity. Several indicators of abdominal obesity such as body mass index (BMI) and waist circumference (WC) are available. BMI and WC have limitations in stratifying cardio-metabolic risks. Another obesity measure, A Body Shape Index (ABSI), has been introduced but its applicability remains limited. To address this, the z-score of the log-transformed ABSI (LBSIZ) was recently develope...